sample="quota" bates="HK1871057" isource="ctr" decade="1970" class="ui" date="19700630" 30 JUNE 1970 ANNUAL MEETING INTRODUCTION CTR- SCIENTIFIC STAFF --S.A.B. -- PLANNING COMMITTEE In light of background just reported--we use this information as a spring board for future planning. 1. Reevaluate existing programs 2. Work toward targeted programs. 3. Efficient use of funds. Brief comment: It is important to realize that final answers to question are not easy: NCI, A.C.S. Nat Heart+Lung Institute Am. Heart Assoc. -all have been funding longer-greater $value! level POINT #1 Refused Projects Can not minimize the effect of refusing to fund programs which will not generate good, useful data. SAB + STAFF more careful scrutinizing Summary: POINT # 2 TO UPDATE PROGRAMS PHASED OUT the following Changing Emphasis We now have answers- Examples: a- Bladder cancer association b) - ulcer association c) Chemistry of Nicotine d) Metabolism of Nicotine e) Various ingredients: Ni, As, Po, Se, aflotoxins f) Development of smoking machines Summary POINT #3. Emphasis has been changed. 1. Nicotine Pharmacology 2. Pure behavioral Psychopharmacology 3. Cells in test tube a) First funded pure technologies CTR first to recognize usefulness b) Tissue culture to organ culture (small sections of human tissues grown in chemical solutions) c) Now apply to human organs d) Now in position to get concrete answers on effect of smoke on human organs 4. Animal models. Change from rats & mice to HAMSTERS CTR foreground NOTE: CTR recognizes that cancer is main prob. chronic pulm. disease next -then C.V.... POINT #4 ACTIVE EVALUATION NOW GOING ON 1. Funded computer-data program usefullness- where do we go ? 2. Has enough work been done on personality studies viz a viz nicotine? 3. Constant surveillance of future hot topic! Collecting literature Library work ie Cd. POINT #5 IMPORTANT WORK COMPLETED (grants-contracts...etc-doesn't matter) CTR wrote , designed, did everything "but diaper the animals". A- Example: a) Cigarette smoking associated by statistics & lung can b) "Tars" from cigarettes cause growths on back mice c) Pipe + Cigar tobacco - no cancer d) " " " tars - equal number of skin painted growths CANT HAVE IT BOTH WAYS B - EXAMPLE Hoffmann said only particulate phase can cause damage + cancer. We initiated studies to show some changes are due to gas phase - can't have it both ways C. Example: Informal Conferences 31 held to date 10-12 scientists per group They get picture of what we are trying to do We got many interested in doing research in area of tobacco + health. generated projects. But: Got many scientists to see this is an open question They relay this idea to their colleagues. Many are now helpful to Industry. POINT 6 WE are on look out for new + useful programs Examples: A. Isreal census bureau. Follow up smoking questions Effect of stress will be assessed. How useful will mail questionnaires be. Set up twin registry B. Georgetown Univ. FAA project (pilots commercial welfare 300-400 men tested 7 years in row Physical, pulmonary function Mass data Statistical analysis Do we tie up? C. New + useful laboratories Cancer Research Institute Columbia, Mo Primate Center NYU 7. New + Redirected Programs Under Action now Contacts Examples A. Check out performance of available smoking machines - keep in foreground of smoking inhalation research. B. Hamster as a model for inhalation Under crit. mouse + rat now... C. Use of tissue culture + virus controls POINT 8 FUTURE Closer control over many projects New areas a) More work on virus origin of cancer. b) " " " Immunology + allergy c) " " " stress on diseases especially biochemical measurements what is real related to cigarettes What part of Auerbach's results are do to extreme stress d) Personality? POINT #9. LAST PART Not to write up Fall out --Aid to Industry. 1. Men - Available for Testimony a) Congress b) witness stand. (short list available) 2. Education at Scientific Meetings CTR Scientists attend - quiet educational job Conference attendees - also are there grantees " " " 3. Speeches + Conferences Platform challenges - Dr Summers Dr Frost within 2 weeks ago 4. Help refute Wild claims Se- West Frost West As: Valley of Harvard Ni Sundman Frost Sundman POINT #10 PROGRESS SLOW BUT DEFINITE These are difficult problems Am. Cancer Soc. National Cancer Institute Am Heart Assoc. National Heart + Lung Institute Have been funding projects many years before us. Institutes also have own research units They have not come any closer than CTR in finding answers In many ways our programs are more immaganative than theirs + we are really getting on target.