sample="quota" bates="81331180" isource="ll" decade="1970" class="ni" date="19790319" Lorillard MEMORANDUM March 19, 1979 TO: Dr. R. S. Marmor Dr. H. J. Minnemeyer Dr. J. R. Reid Dr. H. S. Tong FROM: M. S. Forte' Subject: Mutagenic Evaluation of Tur Compounds All the Tur compounds were tested in the Ames test using the three Salmonella tester strains, TA1535, TA100, and TA98 which are responsive to both base pair and frame shift mutations. The dose level used in the assay for each compound was determined by a preliminary test evaluating the toxicity of the compound to the bacterial strains. Non-toxic, yet adequate doses were employed in all Ames tests. Each Tur compound was found to be non-mutagenic in all strains , with and without microsome, at the dose range given. Therefore, the compounds themselves and their metabolite(s), if any, are not mutagenic according to this test system. M. S. Forte' MSF/le