sample="quota" bates="517904260" isource="rjr" decade="1990" class="ui" date="19950905" Tobacco Chemists' Research Conference INSTRUCTIONS FOR THE PREPARATION OF ABSTRACTS Please type name, address and phone number of principle author below NOTE: The abstract must contain a meaningful summary of the material to be presented. It must include the objectives of the research efforts, the methods used, and the results obtained. The editorial committee reviews and accepts papers based on the abstract. Very short or vague abstracts will not be accepted. Michael F. Borgerding R. J. Reynolds Tobacco Company P. O. Box 1487 Winston-Salem, NC 27102-1487 Approaches to Characterizing Smoke from New Cigarette Designs - A Product Evaluation Strategy. Michael F. Borgerding. R. J. Reynolds Tobacco Company, Winston-Salem, NC 27102-1487. New cigarette components and cigarette designs such as new carbon filters, experimental tobacco blends, and cigarettes which primarily heat, rather than burn, tobacco continue to be developed. An extensive chemical analysis program has been applied to evaluate and characterize cigarette smoke from some of these new cigarettes. This paper will review typical chemical analyses which may be applied to mainstream or sidestream smoke to evaluate new cigarette designs. The role of gross measures (measures based upon a chemical or physical property of smoke total particulate matter), aggregate chemical measures (measures based on a summary chemical response from more than one smoke constituent) and specific compound determinations (quantitative measures of individual smoke constituents) within the context of the analysis program will be addressed. Additionally, study designs for comparing smoke from different cigarettes will be presented. Cigarettes from the current US market, control cigarettes pertinent to the study and University of Kentucky reference cigarettes are each useful for assessing smoke from a new cigarette design. Products chosen to study include a new carbon filter design, an experimental tobacco blend, and a cigarette that primarily heats, rather than burns, tobacco will be described. 1. The abstract should be 180-225 words in length and be included in the space designated above. IN ADDITION TO THE PRINTED COPIES, THE ABSTRACT MUST BE SUBMITTED AS BOTH A WORD PROCESSING FILE AND AN ASCII (TEXT) FILE ON DISKETTE. Label the diskette with the principal author's last name and specify the word processing package used. 2. Please note the following: (a) Title all in capitals, the name of presenting author is underlined. (b) Location and postal/zip code follows author's name, if multiple authors are at different locations. (c) Use 12 point fonts such as Arial or Courier if possible. 3. Mail 5 copies of the abstract and the diskette to: Dr. Harold R. Buerton, University of Kentucky, Rm 212 ASCN, Lexington, KY 40546-0091 4. Abstracts must be received no later than June 10, 1995. 5. Projection requirements: Only 2" x 2" slides (35mm) will be accommodated, with maximum slide thickness of 1/8". COMPANY LOGO IS PERMITTED ONLY ON TITLE SLIDE. 6. The maximum presentation time is 15 minutes, with 5 minutes for discussion. RJRT/RESEARCH & DEVELOPMENT DOCUMENT APPROVAL FORM NAME: Michael F. Borgerding TITLE: Master Chemist DIVISION: Analytical Chemistry TYPE OF DOCUMENTATION: Abstract Res. Manu. Oral Presentation Other DATE: September 5, 1995 MAIL ADDRESS: BGTC - 611-13CO/001 EXTENSION 4933 DOCUMENT TITLE: Approaches to Characterizing Smoke from New Cigarette Designs - A Product Evaluation Strategy AUTHOR(s): M. F. Borgerding TYPIST/STENOGRAPHER: M. F. Borgerding Extension: 4933 PURPOSE OF DOCUMENT PUBLICATION IN: PRESENTATION AT: 1995 TCRC LOCATION: Lexington, KY DATE: Sept. 24, 1995 Other pertinent information: Your signatures on this form indicate that to the best of your knowledge, the information contained in the document to be published/presented is not proprietary and that the technical quality reflects positively on the image of RJRT and its R&D Groups. Author(s): Date: 9/7/95 Reviewer 1: Date: 9/7/95 Reviewer 2: Date: 9/7/95 Division Manager: Date: 9/7/95 RJRT General Law: Date: 9-18-95 RJRT Patent Review: 9/14/95 Group Director: Date: 9/21/95 RJRT Management Date: Approaches to Characterizing Smoke from New Cigarettes - A Product Evaluation Strategy Michael F. Borgerding R. J. Reynolds Tobacco Company Current Product Development Efforts New Carbon filter design Experimental Blend Cigarette which primarily heats tobacco Product Evaluation Strategy to Characterize Smoke from New Cigarette Designs The Opportunity Product Evaluation Study Design Components Cigarettes of Interest Chemical Analyses Each Study Design will be Different Study designs depends upon the nature of the cigarette or cigarette component which is of interest. Potential Products for Study New Products Appropriate Control Cigarettes Cigarettes from the U.S. Market Kentucky Reference Cigarettes Choice of Products Equivalent "tar" comparison Comparison of multiple "tar" categories Potential Smoke Streams for Study: Mainstream Smoke Sidestream Smoke Environmental Tobacco Smoke Chemical Analysis Categories Standard Measures (FTC) Gross Measures Aggregate Chemical Measures Specific Compound Determinations Standard Measures FTC Method - "tar - nicotine - puff count - carbon monoxide Should these Cigarettes be Compared? Are Standard Smoke Yields Equivalent? Gross Measures Measurements based on a chemical or physical property of smoke total particulate matter Examples of Gross Measures Elemental Composition (C, H&N) UV Absorption - Spectophotometric "tar" Thermogravimetric Analysis - volatility - stability Materials Balance Assessment Visual Comparison Aggregate Measures Addresses an open ended question Collective response from many compounds rather than single chemical Comparative measure Aggregate Chemical Measures Chromatographic Profiling - Vapor Phase Number of Peaks Total Peak Response - Particulate Phase Number of Peaks Total Peak Response Vapor Phase Free Radials Specific Compound Determinations "Target" Compound Determinations - Closed ended question - Determine amounts of specific chemicals - Absolute measures "Target Compounds" Studied Product assessment strategy may include ~ 20-30 specific chemicals or "Target Compounds" Compounds Studied Based on Literature - US Surgeon General's Report - IARC Monograph - Consumer Product Safety Commission Potential "Target Compounds" Carbonyls - Formaldehyde - Acetaldehyde - Acetone - Acrolein Hydroxybenzenes - phenol - cresols - catechol - hydroquinone Potential "Target Compounds" Aromatic Amines - 2-aminonapthalene - 4-aminobiphenyl TSNAs - NNN - NAT - NNK Inorganic - Arsenic - Nickel - Chromium - Cadmium Potential "Target Compounds" PAH - Benzo(a)pyrene Aza-arenes - Quinoline Misc. Organic - Benzene - Acrylonitrile Miscellaneous - Ammonia - Nitrogen Oxides - HCN Unsat. Hydrocarbons - Isoprene - 1, 3-butadiene EXP-C Study New Carbon Filter P = Particulate Phase V = Vapor Phase EXP-C Study Test Cigarettes STD-C Standard U.S. Blend Carbon Scrubber Filter EXP-C Experimental Blend Carbon Scrubber Filter EXP Experimental Blend Standard CA Filter EXP-C Study Purchased from U. S. Market FFLT - 2 A Leading "Light" Cigarette FFLT-1 A Leading "Light" Cigarette FFLT-CH Charcoal Filter "Light" Cigarette TOB-HT Study Cigarette That Primarily Heats Tobacco (TOB-HT) TOB-HT Study Test Cigarette / Blank TOB-HT A Cigarette which Primarily Heats Tobacco Blank Smoke collection and analysis conducted with empty smoke machine ports. TOB-HT Study Kentucky Ref. / U. S. Market Cigarettes 1R4F KR "Light" Cigarette 1 R5F KR "UltraLight" Cigarette FFLT - 3 A Leading "Light" Cigarette Summary Components of Product Evaluation Strategy Presented. Different Types of Chemical Analysis Provide Complementary Information for Evaluating New Cigarette Designs Summary Each Study will be Different - Cigarette Design under Study - Chemical Questions Posed Approaches to Categorizing Smoke from New Cigarettes - A Product Evaluation Strategy Michael F. Borgerding R. J. Reynolds Tobacco Company