sample="quota" bates="2501662150" isource="pm" decade="1980" class="ni" date="19870311" Beatsgurg der Obereinstimmung mit dem Original insfo Delum, Unterschrift 8-Apr-87 90,,7+3 8874675 inbi dwu 8874675 inbi d #3625 easylink 7438584a001 11mar87 13:43/13:54 est suspected duplicate from: tlx 350356 pmus st rch ud philip morris usa to: 8418874675 richmond va usa 11 march 1987 12 Marz 1987 ww attention: dr. r.-a. walk dear roger: 08.00 i am sorry not to have been able to return your call this morning. perhaps we can talk again later this week, although i am pretty well tied up both tomorrow morning. maybe early on friday... jim charles, tom, judy, and i had a luncheon meeting today to discuss the feasibility of doing a ms smoke inhalation study at inbifo this year. what i need to hear from you is whether or not such a situation can be done - given the current animal protection situation. if the answer is yes, i need to know when it could be started and ho many cigts would be needed. experimental outline as follows: we hve a need to test a cigt ingredient. we envisage a 90 day ms exposure in rats. there would be 2 cigt types: control and control plus ingredient. we would be interested primarily in respiratory tract histopathology, although you could add whatever other end points you felt were appropriate. as for dose, we would also leave that to you. we do however want to point out that exposure for 7 hroxday, 5 days/wk should suffice= we see no need to do exposures for 7 days/wk. the hoped-for result from the experiment would be to demonstrate no difference between the control and the experimental cigt in respiratory tract histopathology observed following exposure to ms smoke. if and when this experiment can be conducted we are prepared to inform you about the exact nature of the ingredient and its level in the experimental cigt. (it could be of intereet in terms of some of the ss results we have observed with the 2r1 cigt.) please let us know (as soon as possible) the prospects for being able to do such an experiment this year. best regards, bob pages 1987) fiche RAP, call 16.7.2.81 telex: 350356 (pmus st rch ud) mmmm wu 8874675 inbi d