sample="supplemental" bates="2501343358" isource="pm" decade="1990" class="ue" date="19900923" TN1052 Sent to New England Journal 3/9/90 LUNG CANCER AND EXPOSURE TO TOBACCO SMOKE IN THE HOUSEHOLD. To the Editor: Dr. Janerich and his colleaguesı report a statistically significant increased risk of lung cancer (odds ratio 2.07; 95% confidence interval, 1.16 to 3.38) in men and women who had never smoked but were exposed to 25 or more smoker-years during childhood and adolescence. Although there was no statistically significant increased risk for all never smoking men and women exposed during childhood and adolescence, they suggest that early life environmental tobacco smoke exposure increases risk of lung cancer. This suggestion is unconvincing for a number of reasons. First, it ignores by now quite extensive epidemiological evidence showing a complete lack of association between ETS exposure in childhood and risk of lung cancer. As shown in Table 1, relative risk estimates from 11 studies, many involving substantial number of cases and controls, are all non-significant, with as many estimates less than 1.0 as are greater than 1.0. Second, the significance of their reported association is not strong (0.01