sample="quota" bates="2028540117" isource="pm" decade="1990" class="ni" date="19921026" ***Resending note of 26.10.92 16:24 To: HARDCOPY--#PRINTER PMARTIN --VCH0021A Peter Martin From: Wolf Reininghaus Subject: P 0268/2190 Nicotine Accumulation in Hair (PT) Status Oct. 92 Dear Peter: The 2nd part of our study investigating the systematic uptake of nicotine in hair of rats has been postponed until November. This delay was caused by the nonavailability of the equipment used for continuous urine collection in metabolic cages for cms animals. Concerning the nicotine patch experiment, we decided that it has to be regarded and performed as a comprehensive clinical study (a). Thus, physicians for the supervision of such an experiment were contacted and an application for the experiment at the ethics committee (a) has been written. Human hair samples for in vitro exposure have been collected from several probands. The exposure of hair examples to ETS will start next month. Bets regards Bridgit Gerstenberg Study Director (a) in full agreement with the German Arzneimittelgesetz