<note> sample="quota" bates="2024481688" isource="pm" decade="1980" class="ni" date="19820517" </note>

00230827339+ 0 Richmond Akte wui C5/17 0831 pm rd rch 8874675inhi
d please cut here dr. t. s. osdene director of research and extramural
studies philip morris research center richmond with the request to
forward to dr. r. pages no. 314o 17.may 82 pe7 a8 drha/pe re: information
for dr. osdene's presentation significant accomplishments (or events
in 1979 to 1981 dr. page's telex message of 4.may 82 

1. in vivo and in vitro smoke exposure year type of study in vivo
(a) 1979 to 1981 establishment and selection of bioassays for differentiation
of cigarettes continued analyses of morphological, biochemical, immunological
and functional responses of free lung cells 1979 micronucleus analyses
in smoke-exposed hamsters and rats methodolgocial study, comparison
of smoke with and irritating produced by larger generator, maintained
point; larynx morphometry 1980 sister chromatid exchange in bone marrow
of smoke-exposed hamsters. Lung perfusion techniques for analysis
of enzyme induction in smoke-exposed rats (a) in connection with inhalation
studies: cigarette smoke:nicotine diffusion and adsorption on surfaces
of different ph year type of study (in vivo) 1981 sister chromatid
exchange in peripheral Lymphocytes of smoke-exposed rats influence
of restraining and food restriction on prenatal development in rats
comparison of side and mainstream smoke based on equal tpm concentration
in inhalation study of rats. determination of differences in chemical
composition, particle size distribution and biological activity in
vitro 1979 to 1981 sister chromatid exchange in cultured hamster and
human lung cells metabolic cooperation (promotion assay) with cultured
hamster cells keeping pregnant rats in tubes of head-only inhalation
chamber, same conditions as in sham exposure groups of inhalation
studies, no smoke exposure please cut here 2 skin painting studies
year type of study classical screening tests, histology 1979 6th skin
painting, mouse 1980 7/8th ' ' ' ('cocoa study') 9th ' ' ' methodological
development, short-term biochemical responses 1980 pilot study with
2ri on parameters such as ahm and odc ' comparison of condensates
with known tumor rate (from 5th skin painting study) 1981 parallel
studies to 9th skin painting study, comparison of condensate including
trapping methods on the basis of results of these studies the importance
of irritation for the results of the classical screening became evident
please cut here 3 studies with pure substances year type of study
pharmacological studies with nicotine and nicotine derivatives 1979
to 1981 screening of new synthetic compounds continued. improvement
of the test models 1981 beginning with storage of pharmacological
literature in ftr's computer in neuchatel. development of immunological
microassays 1980 and 1981 elisa for nicotine and cotinine please cut
here 4 salmonella mutagenicity assays year type of study 1979 to 1981
establishment and opening of 'ames' Laboratory (1979). routine testing
of condensates and flavors 

best regards, ulrich end of message 14.49 8874675 inbi d pm rd rch