sample="quota" bates="2022177237" isource="pm" decade="1960" class="ni" date="19640422" 706 708 PHILIP MORRIS INCORPORATED INTER-OFFICE CORRESPONDENCE RICHMOND, VIRGINIA To: Dr. A. Bavley Date: April 22, 1964 From: R.D. Carpenter Subject: FASEB Meeting in Chicago, Illinois - April 13-16, 1964 Several papers evoked a great deal of interest at this meeting. I will report on the actual papers later, but I want to record impressions and information picked up during the meeting. The paper presented by FDRL on mucus flow was received with considerable interest. Dr. Kensler and Mr. Battista of A. D. Little, Inc. were particularly interested. Mr. Battista commented, "We are glad to see you have confirmed our results" . Dr. Kensler commented to Dr. Carson that he thought we had gone about as far as we can in obtaining improvements in cigarettes as far as their effects on mucus flow and respiratory dynamics. Apparently the ADL people have progressed far enough in the study of respiratory dynamics to know something of the response to various commercial cigarettes. I believe Dr. Kensler's statement was meant to draw some response from Dr. Carson, and I doubt that he intends to stop working in those areas. He emphasized that he thought further improvements would have to be made in other areas. I presume he meant the area of carcinogenesis. The American Tobacco Company was represented by Mr. Tom Vaughn. He told me that he did not know that we were working in this area. He seemed to be impressed by the work reported. One question concerning Mr. Goldhammer's paper asked if the method did not, in effect, measure ciliary beat frequency, but he had not understood the effects measured were immediate rather than delayed. The Physiology Section had a number of papers concerning surface activity of l o ung extracts. This subject was one of great interest to many of the people present. The surfactants in the lung have rather marked effects on the compliance and elastance. I believe the most informative part of this trip was the return flight. My seat partner was Dr. Glen B. Haydon, who is with the Palo Alto Medical Research Foundation. Dr. Haydon is conducting a study on the chronic effects of air pollutants on the lung. He has exposed rats to very low concentrations of NO2 (ca. 0.025 ppm) for extended periods. After one year the rats were sacrificed and their lungs were examined. He showed me slides which showed a definite thickening of the alveolar walls and an enlargement of the ducts. The control rats did not exhibit this thickening and enlargement. Dr. Haydon said these changes were definitely emphysemous. In addition, he had observed a definite thickening - almost a "crusting" - of the mucus in the tracheas of the rats. Dr. Haydon feels that the emphasis on lung cancer is obscuring the problem of bronchitis and emphysema in the public eye. This feeling is natural for him, since he is not studying lung cancer. He is, however, a pathologist, and as such should be a reliable judge of the relative importance of the two problems. /cb cc: Dr. H. Wakeham