<note> sample="quota" bates="03750675" isource="ll" decade="1970" class="ni" date="19781023" </note>

HARVARD MEDICAL SCHOOL BETH ISRAEL HOSPITAL DEPARTMENT OF MEDICINE
CARDIOVASCULAR UNIT MAILING ADDRESS: BETH ISRAEL HOSPITAL 330 BROOKLINE
AVENUE BOSTON, MASSACHUSETTS 02215 617-735-3445 October 23, 1978 Dr.
Gary L. Huber Beth Israel Hospital KB-23 Dear Gary: 

In response to your memo of October 11th, please find enclosed herewith
an updated report on our research on the "cardiovascular effects of
cigarrette smoke". Since the last report, the studies of the acute
hemodynamic effects of cigarette smoke in man have been extended by
doubling the group of normal subjects to 32. This work was presented
to the VIII World Congress of Cardiology in Tokyo in September of
thisyear. A copy of the presentation with illustrations, as well as
a copy of the published abstract, are enclosed. Similar studies of
patients with heart disease are in progress. An in-depth study of
the effects of acetaldehyde upon heart muscle in vitro is in progress.
Dr. Rabinowitz' paper (reference #8) has been reviewed by Circulation.
It was returned with an invitation to resubmit it with relatively
minor modifications. Kindly let me have the material you had wished
included at your earliest convenience. This should include the results
of the nicotine assay of the cigarettes used, as specifically requested
by one reviewer. 

With Best regards, I am Very Sincerely yours, Walter H. Abelmann,
M.D. WHA: ms Enclosures cc: Dr. Bing Dr. Rabinowitz Dr. Sakurai Ms.
Thorp